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No SARS-CoV-2 detection in the German CAPNETZ cohort of community acquired pneumonia before COVID-19 peak in March 2020. Panning M, Wiener J, Rothe K, Schneider J, Pletz MW, Rohde G, Rupp J, Witzenrath M, Spinner CD; Members of the CAPNETZ study group. Infection. 2020 Jul 3. doi: 10.1007/s15010-020-01471-y.
Microbiota-associated risk factors for C. difficile acquisition in hospitalized patients: A prospective, multicentric study. Solbach P, Chhatwal P, Woltemate S, Tacconelli E, Buhl M, Autenrieth IB, Vehreschild MJGT, Jazmati N, Gerhard M, Stein-Thoeringer CK, Rupp J, Ulm K, Ott A, Lasch F, Koch A, Manns MP, Suerbaum S, Bachmann O. Clin Infect Dis. 2020 Jun 26:ciaa871. doi: 10.1093/cid/ciaa871. Online ahead of print.Clin Infect Dis. 2020. PMID: 32589701
The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia. Gröschel MI, Meehan CJ, Barilar I, Diricks M, Gonzaga A, Steglich M, Conchillo-Solé O, Scherer IC, Mamat U, Luz CF, De Bruyne K, Utpatel C, Yero D, Gibert I, Daura X, Kampmeier S, Rahman NA, Kresken M, van der Werf TS, Alio I, Streit WR, Zhou K, Schwartz T, Rossen JWA, Farhat MR, Schaible UE, Nübel U, Rupp J, Steinmann J, Niemann S, Kohl TA.Gröschel MI, et al. Nat Commun. 2020 Apr 27;11(1):2044. doi: 10.1038/s41467-020-15123-0.
Dissimilarity of Airway and Lung Tissue Microbiota in Smokers undergoing Surgery for Lung Cancer. Reinhold L, Möllering A, Wallis S, Palade E, Schäfer K, Drömann D, Rupp J, Graspeuntner S, Dalhoff K. Microorganisms. 2020 May 26;8(6):E794. doi: 10.3390/microorganisms8060794.
Pro-inflammatory cytokine ratios determine the clinical course of febrile neutropenia in children receiving chemotherapy. Siegmund M, Pagel J, Scholz T, Rupp J, Härtel C, Lauten M. Mol Cell Pediatr. 2020 Jun 9;7(1):5. doi: 10.1186/s40348-020-00097-2.
Chronic liver disease negatively affects outcome in hospitalised patients with community-acquired pneumonia. Bellinghausen C, Pletz MW, Rupp J, Witzenrath M, Welsch C, Zeuzem S, Trebicka J, Rohde GGU; Members of the CAPNETZ study group. Gut. 2020 Apr 6. pii: gutjnl-2020-320876. doi: 10.1136/gutjnl-2020-320876.
[The new comprehension of pulmonary infections]. Hörster R, Rupp J. Pneumologe (Berl). 2020;17(2):105-112. doi: 10.1007/s10405-019-00291-8.

Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice. Sünderhauf A, Pagel R, Künstner A, Wagner AE, Rupp J, Ibrahim SM, Derer S, Sina C. Nutrients. 2020 Apr 17;12(4). pii: E1122. doi: 10.3390/nu12041122.

Lactobacillus Acidophilus/Bifidobacterium Infantis Probiotics Are Beneficial to Extremely Low Gestational Age Infants Fed Human Milk. Fortmann I, Marißen J, Siller B, Spiegler J, Humberg A, Hanke K, Faust K, Pagel J, Eyvazzadeh L, Brenner K, Roll C, Pirr S, Viemann D, Stavropoulou D, Henneke P, Tröger B, Körner T, Stein A, Derouet C, Zemlin M, Wieg C, Rupp J, Herting E, Göpel W, Härtel C. Nutrients. 2020 Mar 22;12(3). pii: E850. doi: 10.3390/nu12030850.

Infection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis in epithelial cells. Maffei B, Laverrière M, Wu Y, Triboulet S, Perrinet S, Duchateau M, Matondo M, Hollis RL, Gourley C, Rupp J, Keillor JW, Subtil A. EMBO J. 2020 Mar 5:e102166. doi: 10.15252/embj.2019102166.

Prevalence of third-generation cephalosporin-resistant Enterobacterales colonization on hospital admission and ESBL genotype-specific risk factors: a cross-sectional study in six German university hospitals. Rohde AM, Zweigner J, Wiese-Posselt M, Schwab F, Behnke M, Kola A, Schröder W, Peter S, Tacconelli E, Wille T, Feihl S, Querbach C, Gebhardt F, Gölz H, Schneider C, Mischnik A, Vehreschild MJGT, Seifert H, Kern WV, Gastmeier P, Hamprecht A; DZIF-ATHOS Study Group . J Antimicrob Chemother. 2020 Mar 16. pii: dkaa052. doi: 10.1093/jac/dkaa052.

Update on the "Choosing Wisely" initiative in infectious diseases in Germany. Draenert R, Jung N; Choosing Wisely (Klug entscheiden) DGI Working Group. Infection. 2020 Mar 10. doi: 10.1007/s15010-020-01400-z.

Immune checkpoint inhibitors and tuberculosis: an old disease in a new context. Langan EA, Graetz V, Allerheiligen J, Zillikens D, Rupp J, Terheyden P. Lancet Oncol. 2020 Jan;21(1):e55-e65. doi: 10.1016/S1470-2045(19)30674-6.

Annexin V expression on CD4+ T cells with regulatory function. Bollinger AL, Bollinger T, Rupp J, Shima K, Gross N, Padayachy L, Chicheportiche R, Puga Yung GL, Seebach JD. Immunology. 2020 Feb;159(2):205-220. doi: 10.1111/imm.13140.

Pharmacokinetics and safety of aztreonam/avibactam for the treatment of complicated intra-abdominal infections in hospitalized adults: results from the REJUVENATE study. Cornely OA, Cisneros JM, Torre-Cisneros J, Rodríguez-Hernández MJ, Tallón-Aguilar L, Calbo E, Horcajada JP, Queckenberg C, Zettelmeyer U, Arenz D, Rosso-Fernández CM, Jiménez-Jorge S, Turner G, Raber S, O'Brien S, Luckey A; COMBACTE-CARE consortium/REJUVENATE Study Group. J Antimicrob Chemother. 2020 Mar 1;75(3):618-627. doi: 10.1093/jac/dkz497.

Pneumococcal conjugate serotype distribution and predominating role of serotype 3 in German adults with community-acquired pneumonia. Forstner C, Kolditz M, Kesselmeier M, Ewig S, Rohde G, Barten-Neiner G, Rupp J, Witzenrath M, Welte T, Pletz MW; CAPNETZ study group. Vaccine. 2020 Jan 29;38(5):1129-1136. doi: 10.1016/j.vaccine.2019.11.026.

Rate and Predictors of Bacteremia in Afebrile Community-Acquired Pneumonia. Forstner C, Patchev V, Rohde G, Rupp J, Witzenrath M, Welte T, Burgmann H, Pletz MW; CAPNETZ Study Group. Chest. 2020 Mar;157(3):529-539. doi: 10.1016/j.chest.2019.10.006.


[Lemierre syndrome - a frequently overlooked infectious disease]. Joost A, Loose S, Kramme E, Derad I. Dtsch Med Wochenschr. 2019 Oct;144(20):1449-1454.

Macrolide combination therapy for hospitalised CAP patients? An individualised approach supported by machine learning. König R, Cao X, Oswald M, Forstner C, Rohde G, Rupp J, Witzenrath M, Welte T, Kolditz M, Pletz M; CAPNETZ study group. Eur Respir J. 2019 Sep 19. pii: 1900824. doi: 10.1183/13993003.00824-2019.

Detection of High-Level Rifaximin Resistance in Enteric Bacteria by Agar Screen. Baumert PMP, Camp J, Gölz H, Vavra M, Schuster S, Kern WV, Mischnik A; DZIF-ATHOS Study Group. Microb Drug Resist. 2019 Dec 19. doi: 10.1089/mdr.2019.0295.

The landscape of diagnostic mycobacteriology in Germany-challenges of decentralised care. Maurer FP, Mintken E, Rupp J, Olaru I, Kranzer K. Int J Tuberc Lung Dis. 2019 Aug 1;23(8):913-918. doi: 10.5588/ijtld.18.0763.

[Hospital-acquired pneumonia - new guidelines]. Kramme E, Dalhoff K. Dtsch Med Wochenschr. 2019 Jun;144(11):724-728. doi: 10.1055/a-0652-8351.

Prevalence and Etiology of Community-acquired Pneumonia in Immunocompromised Patients. Di Pasquale MF, Sotgiu G, Gramegna A, Radovanovic D, Terraneo S, Reyes LF, Rupp J, González Del Castillo J, Blasi F, Aliberti S, Restrepo MI; GLIMP Investigators. Clin Infect Dis. 2019 Apr 24;68(9):1482-1493. doi: 10.1093/cid/ciy723.

Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia. Villafuerte D, Aliberti S, Soni NJ, Faverio P, Marcos PJ, Wunderink RG, Rodriguez A, Sibila O, Sanz F, Martin-Loeches I, Menzella F, Reyes LF, Jankovic M, Spielmanns M, Restrepo MI; GLIMP Investigators. Respirology. 2019 Aug 5. doi: 10.1111/resp.13663. [Epub ahead of print]

Maternally Inherited Differences within Mitochondrial Complex I Control Murine Healthspan. Hirose M, Schilf P, Zarse K, Busch H, Fuellen G, Jöhren O, Köhling R, König IR, Richer B, Rupp J, Schwaninger M, Seeger K, Sina C, Ristow M, Ibrahim SM. Genes (Basel). 2019 Jul 13;10(7). pii: E532. doi: 10.3390/genes10070532.

Elaborations on Corallopyronin A as a Novel Treatment Strategy Against Genital Chlamydial Infections. Loeper N, Graspeuntner S, Ledig S, Kaufhold I, Hoellen F, Schiefer A, Henrichfreise B, Pfarr K, Hoerauf A, Shima K, Rupp J. Front Microbiol. 2019 May 7;10:943. doi: 10.3389/fmicb.2019.00943. eCollection 2019.

[Enterococci With Special Resistance Patterns - Epidemiology, Hygiene and Therapy]. Mischnik A, Werner G, Bender J, Mutters NT. Dtsch Med Wochenschr. 2019 Apr;144(8):553-560. doi: 10.1055/a-0655-6454. Epub 2019 Apr 15. German.

The HIF-1α/LC3-II-axis impacts on fungal immunity in human macrophages. Friedrich D, Zapf D, Lohse B, Fecher RA, Deepe GS Jr, Rupp J. Infect Immun. 2019 Apr 29. pii: IAI.00125-19. doi: 10.1128/IAI.00125-19. [Epub ahead of print]

A Natural mtDNA Polymorphism in Complex III Is a Modifier of Healthspan in Mice. Hirose M, Künstner A, Schilf P, Tietjen AK, Jöhren O, Huebbe P, Rimbach G, Rupp J, Schwaninger M, Busch H, Ibrahim SM. Int J Mol Sci. 2019 May 13;20(9). pii: E2359. doi: 10.3390/ijms20092359.

The monocyte-dependent immune response to bacteria is suppressed in smoking-induced COPD. Knobloch J, Panek S, Yanik SD, Jamal Jameel K, Bendella Z, Jungck D, Bürger P, Bülthoff E, Struck B, Giannakis N, Rupp J, Kronsbein J, Peters M, Koch A. J Mol Med (Berl). 2019 Mar 30. doi: 10.1007/s00109-019-01778-w. [Epub ahead of print]

Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia - results from the prospective observational PROGRESS study. Ahnert P, Creutz P, Horn K, Schwarzenberger F, Kiehntopf M, Hossain H, Bauer M, Brunkhorst FM, Reinhart K, Völker U, Chakraborty T, Witzenrath M, Löffler M, Suttorp N, Scholz M; PROGRESS Study Group. Crit Care. 2019 Apr 4;23(1):110.

An international perspective on hospitalized patients with viral community-acquired pneumonia. Radovanovic D, Sotgiu G, Jankovic M, Mahesh PA, Marcos PJ, Abdalla MI, et al. Eur J Intern Med. 2019 Feb;60:54-70.

After standard dosage of piperacillin plasma concentrations of drug are subtherapeutic in burn patients. Olbrisch K, Kisch T, Thern J, Kramme E, Rupp J, Graf T, Wicha SG, Mailänder P, Raasch W. Naunyn Schmiedebergs Arch Pharmacol. 2019 Feb;392(2):229-241.

Differential drug susceptibility patterns of Mycobacterium chimaera and other members of the Mycobacterium avium-intracellulare complex. Maurer FP, Pohle P, Kernbach M, Sievert D, Hillemann D, Rupp J, Hombach M, Kranzer K. Clin Microbiol Infect. 2019 Mar;25(3):379.e1-379.e7.

Dietary ursolic acid improves health span and life span in male Drosophila melanogaster. Staats S, Wagner AE, Lüersen K, Künstner A, Meyer T, Kahns AK, Derer S, Graspeuntner S, Rupp J, Busch H, Sina C, Ipharraguerre IR, Rimbach G. Biofactors. 2019 Mar;45(2):169-186. doi: 10.1002/biof.1467. Epub 2018 Nov 29.


Incidence of infections due to third generation cephalosporin-resistant Enterobacteriaceae - a prospective multicentre cohort study in six German university hospitals. Rohde AM, Zweigner J, Wiese-Posselt M, Schwab F, Behnke M, Kola A, Obermann B, Knobloch JK, Feihl S, Querbach C, Gebhardt F, Mischnik A, Ihle V, Schröder W, Armean S, Peter S, Tacconelli E, Hamprecht A, Seifert H, Vehreschild MJGT, Kern WV, Gastmeier P; DZIF-ATHOS study group. Antimicrob Resist Infect Control. 2018 Dec 27;7:159. doi: 10.1186/s13756-018-0452-8. eCollection 2018.

[New β‑lactam antibiotics and β‑lactamase inhibitors against multidrug-resistant Gram-negative bacteria]. Mischnik A, Lübbert C, Mutters NT. Internist (Berl). 2018 Dec;59(12):1335-1343. doi: 10.1007/s00108-018-0508-0. Review. German.

Gut dysbiosis with Bacilli dominance and accumulation of fermentation products precedes late-onset sepsis in preterm infants. Graspeuntner S, Waschina S, Künzel S, Twisselmann N, Rausch TK, Cloppenborg-Schmidt K, Zimmermann J, Viemann D, Herting E, Göpel W, Baines JF, Kaleta C, Rupp J, Härtel C, Pagel J. Clin Infect Dis. 2018 Oct 16. doi: 10.1093/cid/ciy882.

The Genetic Transformation of Chlamydia pneumoniae. Shima K, Wanker M, Skilton RJ, Cutcliffe LT, Schnee C, Kohl TA, Niemann S, Geijo J, Klinger M, Timms P, Rattei T, Sachse K, Clarke IN, Rupp J. mSphere. 2018 Oct 10;3(5). pii: e00412-18. doi: 10.1128/mSphere.00412-18.

Effective inhibition of rifampin-resistant Chlamydia trachomatis by the novel DNA-dependent RNA-polymerase inhibitor Corallopyronin A. Shima K, Ledig S, Loeper N, Schiefer A, Pfarr K, Hoerauf A, Graspeuntner S, Rupp J. Int J Antimicrob Agents. 2018 Aug 6. pii: S0924-8579(18)30224-3. doi: 10.1016/j.ijantimicag.2018.07.025.

Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective. Gramegna A, Sotgiu G, Di Pasquale M, Radovanovic D, Terraneo S, Reyes LF, Vendrell E, Neves J, Menzella F, Blasi F, Aliberti S, Restrepo MI; GLIMP Study Group. BMC Infect Dis. 2018 Dec 18;18(1):677. doi: 10.1186/s12879-018-3565-z

Microbiological testing of adults hospitalised with community-acquired pneumonia: an international study. Carugati M, Aliberti S, Reyes LF, Franco Sadud R, Irfan M, Prat C, Soni NJ, Faverio P, Gori A, Blasi F, Restrepo MI; GLIMP. ERJ Open Res. 2018 Oct 8;4(4). pii: 00096-2018. doi: 10.1183/23120541.00096-2018.

Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: a multinational point prevalence study of hospitalised patients. Restrepo MI, Babu BL, Reyes LF, Chalmers JD, Soni NJ, Sibila O, Faverio P, Cilloniz C, Rodriguez-Cintron W, Aliberti S; GLIMP. Eur Respir J. 2018 Aug 9;52(2). pii: 1701190. doi: 10.1183/13993003.01190-2017. Print 2018 Aug.

Lithocholic Acid Significantly Improves the Survival of Drosophila Melanogaster. Staats S, Rimbach G, Kuenstner A, Graspeuntner S, Rupp J, Busch H, Sina C, Ipharraguerre IR, Wagner AE. Mol Nutr Food Res. 2018 Jul 27:e1800424. doi: 10.1002/mnfr.201800424. [Epub ahead of print]

Selection of validated hypervariable regions is crucial in 16S-based microbiota studies of the female genital tract. Graspeuntner S, Loeper N, Künzel S, Baines JF, Rupp J. Sci Rep. 2018 Jun 26;8(1):9678. doi: 10.1038/s41598-018-27757-8.

Type-1 interferons prolong the lifespan of neutrophils by interfering with members of the apoptotic cascade. Aga E, Mukherjee A, Rane D, More V, Patil T, van Zandbergen G, Solbach W, Dandapat J, Tackenberg H, Ohms M, Sarkar A, Laskay T. Cytokine. 2018 Dec;112:21-26.

Interferon-γ interferes with host cell metabolism during intracellular Chlamydia trachomatis infection. Shima K, Kaeding N, Ogunsulire IM, Kaufhold I, Klinger M, Rupp J. Cytokine. 2018 Jun 6. pii: S1043-4666(18)30237-0. doi: 10.1016/j.cyto.2018.05.039. [Epub ahead of print]

Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants. Hartz A, Schreiter L, Pagel J, Moser K, Wieg C, Grotheer A, Rupp J, Herting E, Göpel W, Härtel C. Pediatr Res. 2018 May 28. doi: 10.1038/s41390-018-0017-9. [Epub ahead of print]

BaiCD gene cluster abundance is negatively correlated with Clostridium difficile infection. Solbach P, Chhatwal P, Woltemate S, Tacconelli E, Buhl M, Gerhard M, Thoeringer CK, Vehreschild MJGT, Jazmati N, Rupp J, Manns MP, Bachmann O, Suerbaum S. PLoS One. 2018 May 8;13(5):e0196977. doi: 10.1371/journal.pone.0196977. eCollection 2018.

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice. Hirose M, Schilf P, Gupta Y, Zarse K, Künstner A, Fähnrich A, Busch H, Yin J, Wright MN, Ziegler A, Vallier M, Belheouane M, Baines JF, Tautz D, Johann K, Oelkrug R, Mittag J, Lehnert H, Othman A, Jöhren O, Schwaninger M, Prehn C, Adamski J, Shima K, Rupp J, Häsler R, Fuellen G, Köhling R, Ristow M, Ibrahim SM. Sci Rep. 2018 Apr 12;8(1):5872. doi: 10.1038/s41598-018-24290-6.

Chemogenomic profiling of human and microbial FK506-binding proteins. Pomplun S, Sippel C, Hähle A, Tay D, Shima K, Klages A, Ünal CM, Rieß B, Toh HT, Hansen G, Yoon HS, Bracher A, Preiser PR, Rupp J, Steinert M, Hausch F. J Med Chem. 2018 Mar 26. doi: 10.1021/acs.jmedchem.8b00137. [Epub ahead of print]

Antifungal Treatment and Outcome in Very-Low-Birth-Weight-Infants - A Population-Based Observational Study of the German Neonatal Network. Fortmann I, Hartz A, Paul P, Pulzer F, Müller A, Böttger R, Proquitté H, Dawczynski K, Simon A, Rupp J, Herting E, Göpel W, Härtel C; German Neonatal Network. Pediatr Infect Dis J. 2018 Mar 29. doi: 10.1097/INF.0000000000002001. [Epub ahead of print]

Pathogenetic and clinical aspects of ANCA-associated vasculitides. Lamprecht P, Kerstein A, Klapa S, Schinke S, Karsten CM, Yu X, Ehlers M, Epplen J, Holl-Ulrich K, Wiech T, Kalies K, Lange T, Laudien M, Laskay T, Gemoll T, Schumacher U, Ullrich S, Busch H, Ibrahim S, Fischer N, Hasselbacher K, Pries R, Petersen F, Weppner G, Manz RA, Humrich JY, Nieberding R, Riemekasten G, Mueller A. Front Immunol 2018; in press

High admission prevalence of fluoroquinolone resistance in third-generation cephalosporin-resistant Enterobacteriaceae in German university hospitals. Rohde AM, Wiese-Posselt M, Zweigner J, Schwab F, Mischnik A, Seifert H, Gastmeier P, Kern WV; DZIF-ATHOS Study Group. J Antimicrob Chemother. 2018 Feb 27.

Microbiota changes impact on sexually transmitted infections and the development of pelvic inflammatory disease. Loeper N, Graspeuntner S, Rupp J. Microbes Infect. 2018 Feb 13. pii: S1286-4579(18)30047-9.

Whole-Genome Expression Profiling in Skin Reveals SYK As a Key Regulator of Inflammation in Experimental Epidermolysis Bullosa Acquisita. Samavedam UK, Mitschker N, Kasprick A, Bieber K, Schmidt E, Laskay T, Recke A, Goletz S, Vidarsson G, Schulze FS, Armbrust M, Schulze Dieckhoff K, Pas HH, Jonkman MF, Kalies K, Zillikens D, Gupta Y, Ibrahim SM, Ludwig RJ. Front Immunol. 2018 Feb 15;9:249. doi: 10.3389/fimmu.2018.00249. eCollection 2018.

[Epidemiology, Diagnosis and Treatment of Adult Patients with Nosocomial Pneumonia - Update 2017 - S3 Guideline of the German Society for Anaesthesiology and Intensive Care Medicine, the German Society for Infectious Diseases, the German Society for Hygiene and Microbiology, the German Respiratory Society and the Paul-Ehrlich-Society for Chemotherapy, the German Radiological Society and the Society for Virology]. Dalhoff K, Abele-Horn M, Andreas S, Deja M, Ewig S, Gastmeier P, Gatermann S, Gerlach H, Grabein B, Heußel CP, Höffken G, Kolditz M, Kramme E, Kühl H, Lange C, Mayer K, Nachtigall I, Panning M, Pletz M, Rath PM, Rohde G, Rosseau S, Schaaf B, Schreiter D, Schütte H, Seifert H, Spies C, Welte T; Unter Mitwirkung der folgenden Wissenschaftlichen Fachgesellschaften und Institutionen: Deutsche Gesellschaft für Chirurgie; Deutsche Gesellschaft für Innere Medizin e. V; Deutsche Gesellschaft für Internistische Intensivmedizin und Notfallmedizin; Deutsche Sepsis-Gesellschaft e. V; und Robert Koch-Institut. Pneumologie. 2018 Jan;72(1):15-63. doi: 10.1055/s-0043-121734.

Microbiota-based analysis reveals specific bacterial traits and a novel strategy for the diagnosis of infectious infertility. Graspeuntner S, Bohlmann MK, Gillmann K, Speer R, Kuenzel S, Mark H, Hoellen F, Lettau R, Griesinger G, König IR, Baines JF, Rupp J. PLoS One. 2018 Jan 9;13(1):e0191047.

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans. Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR, Opitz B; CAPNETZ Study Group. PLoS Pathog. 2018 Jan 3;14(1):e1006829. doi: 10.1371/journal.ppat.1006829. [Epub ahead of print]

Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2. Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalick L, Kuebler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ Study Group. Crit Care Med. 2018 Jan 2. doi: 10.1097/CCM.0000000000002916.

Extended-pulsed fidaxomicin versus vancomycin for Clostridium difficile infection in patients 60 years and older (EXTEND): a randomised, controlled, open-label, phase 3b/4 trial. Guery B, Menichetti F, Anttila VJ, Adomakoh N, Aguado JM, Bisnauthsing K, Georgopali A, Goldenberg SD, Karas A, Kazeem G, Longshaw C, Palacios-Fabrega JA, Cornely OA, Vehreschild MJGT; EXTEND Clinical Study Group. Lancet Infect Dis. 2017 Dec 19. pii: S1473-3099(17)30751-X. doi: 10.1016/S1473-3099(17)30751-X.     

Changes in Neutrophil Metabolism upon Activation and Aging. Richer BC, Salei N, Laskay T, Seeger K. Inflammation. 2018 Jan 10. doi: 10.1007/s10753-017-0725-z.


Extended-pulsed fidaxomicin versus vancomycin for Clostridium difficile infection in patients 60 years and older (EXTEND): a randomised, controlled, open-label, phase 3b/4 trial. Guery B, Menichetti F, Anttila VJ, Adomakoh N, Aguado JM, Bisnauthsing K, Georgopali A, Goldenberg SD, Karas A, Kazeem G, Longshaw C, Palacios-Fabrega JA, Cornely OA, Vehreschild MJGT; EXTEND Clinical Study Group. Lancet Infect Dis. 2017 Dec 19. pii: S1473-3099(17)30751-X. doi: 10.1016/S1473-3099(17)30751-X.     

[Hospital Antibiotic Stewardship - New Guidelines and New Findings]. de With K, Wilke K, Först G, Kramme E, Kern WV. Dtsch Med Wochenschr. 2017 Feb;142(3):177-182. doi: 10.1055/s-0042-121745.

Growth of Chlamydia pneumoniae Is Enhanced in Cells with Impaired Mitochondrial Function. Käding N, Kaufhold I, Müller C, Szaszák M, Shima K, Weinmaier T, Lomas R, Conesa A, Schmitt-Kopplin P, Rattei T, Rupp J. Front Cell Infect Microbiol. 2017 Dec 5;7:499. doi: 10.3389/fcimb.2017.00499. eCollection 2017.

Accurate HCV genotyping and selection of optimal therapy: lessons from a St. Petersburg strain infection. Knops E, Heger E, Koenig C, Moebius U, Lübke N, Kaiser R, Di Cristanziano V, Hüsgen L, Kocyigit C, Rupp J, Sierra S. Clin Microbiol Infect. 2017 Nov 2. pii: S1198-743X(17)30598-0. doi: 10.1016/j.cmi.2017.10.025.

Mitochondrial gene polymorphism is associated with gut microbial communities in mice. Hirose M, Künstner A, Schilf P, Sünderhauf A, Rupp J, Jöhren O, Schwaninger M, Sina C, Baines JF, Ibrahim SM. Sci Rep. 2017 Nov 10;7(1):15293. doi: 10.1038/s41598-017-15377-7.

Regulatory T Cells Suppress Inflammation and Blistering in Pemphigoid Diseases. Bieber K, Sun S, Witte M, Kasprick A, Beltsiou F, Behnen M, Laskay T, Schulze FS, Pipi E, Reichhelm N, Pagel R, Zillikens D, Schmidt E, Sparwasser T, Kalies K, Ludwig RJ. Front Immunol. 2017 Nov 24;8:1628. doi: 10.3389/fimmu.2017.01628. eCollection 2017.

Microbiomarkers in inflammatory bowel diseases: caveats come with caviar. Sommer F, Rühlemann MC, Bang C, Höppner M, Rehman A, Kaleta C, Schmitt-Kopplin P, Dempfle A, Weidinger S, Ellinghaus E, Krauss-Etschmann S, Schmidt-Arras D, Aden K, Schulte D, Ellinghaus D, Schreiber S, Tholey A, Rupp J, Laudes M, Baines JF, Rosenstiel P, Franke A. Gut. 2017 Jul 21. pii: gutjnl-2016-313678. doi: 10.1136/gutjnl-2016-313678.

Nontypeable Haemophilus influenzae (NTHi) directly interfere with the regulation of E-cadherin in lung epithelial cells. Kaufhold I, Osbahr S, Shima K, Marwitz S, Rohmann K, Drömann D, Goldmann T, Dalhoff K, Rupp J. Microbes Infect. 2017 Aug 10. pii: S1286-4579(17)30116-8. doi: 10.1016/j.micinf.2017.07.002.

Lactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics. Härtel C, Pagel J, Spiegler J, Buma J, Henneke P, Zemlin M, Viemann D, Gille C, Gehring S, Frommhold D, Rupp J, Herting E, Göpel W. Sci Rep. 2017 Jul 17;7(1):5633. doi: 10.1038/s41598-017-06161-8.

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling. Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S. Nat Med. 2017 Jul;23(7):829-838. doi: 10.1038/nm.4346.

The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants.Hartz A, Pagel J, Humberg A, Preuss M, Schreiter L, Rupp J, Figge J, Karsten CM, Nürnberg P, Herting E, Göpel W, Härtel C; German Neonatal Network (GNN). PLoS One. 2017 May 30;12(5):e0178032. doi: 10.1371/journal.pone.0178032. eCollection 2017.

IL-1β induced HIF-1α inhibits the differentiation of human FOXP3+ T cells. Feldhoff LM, Rueda CM, Moreno-Fernandez ME, Sauer J, Jackson CM, Chougnet CA, Rupp J. Sci Rep. 2017 Mar 28;7(1):465. doi: 10.1038/s41598-017-00508-x.   

Early Production of the Neutrophil-Derived Lipid Mediators LTB4 and LXA4 Is Modulated by Intracellular Infection with Leishmania major. Plagge M, Laskay T. Biomed Res Int. 2017;2017:2014583. doi: 10.1155/2017/2014583.

[Strategies for the Treatment of Community-Acquired Pneumonia in HIV-Positive Patients]. Schleenvoigt BT, Rupp J, Rohde G, Rockstroh JK, Fätkenheuer G, Pletz MW. Pneumologie. 2017 Apr;71(4):207-214. doi: 10.1055/s-0043-101254. Epub 2017 Apr 13. German.

Hypoxia and host pathogen responses. Walmsley SR, Rupp J. Microbes Infect. 2017 Jan 20. pii: S1286-4579(17)30020-5. doi: 10.1016/j.micinf.2017.01.006.

Extracellular Acidification Inhibits the ROS-Dependent Formation of Neutrophil Extracellular Traps. Behnen M, Möller S, Brozek A, Klinger M, Laskay T. Front Immunol. 2017 Feb 28;8:184. doi: 10.3389/fimmu.2017.00184. eCollection 2017 Feb 28.

Bacterial aetiology and mortality in COPD patients with CAP: results from the German Competence Network, CAPNETZ. Braeken DC, Franssen FM, von Baum H, Schütte H, Pletz MW, Rupp J, Stassen F, Mooij MJ, Rohde GG. Int J Tuberc Lung Dis. 2017 Feb 1;21(2):236-243. doi: 10.5588/ijtld.16.0567.

Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity. Friedrich D, Fecher RA, Rupp J, Deepe GS Jr. Microbes Infect. 2017 Mar;19(3):204-209. doi: 10.1016/j.micinf.2016.10.008.

Enhanced survival of Leishmania major in neutrophil granulocytes in the presence of apoptotic cells. Salei N, Hellberg L, Köhl J, Laskay T. PLoS One. 2017 Feb 10;12(2):e0171850. doi: 10.1371/journal.pone.0171850.

Serological signatures of clinical cure following successful treatment with sodium stibogluconate in Ethiopian visceral leishmaniasis. Gadisa E, Tasew G, Abera A, Gelaye W, Chanyalew M, Abebe M, Laskay T, Aseffa A. Cytokine. 2017 Mar;91:6-9. doi: 10.1016/j.cyto.2016.11.016.


Interferon Regulatory Factor 4 controls TH1 cell effector function and metabolism. Mahnke J, Schumacher V, Ahrens S, Käding N, Feldhoff LM, Huber M, Rupp J, Raczkowski F, Mittrücker HW. Sci Rep. 2016 Oct 20;6:35521. doi: 10.1038/srep35521.

Preterm Birth during Influenza Season Is Associated with Adverse Outcome in Very Low Birth Weight Infants. Härtel C, Humberg A, Viemann D, Stein A, Orlikowsky T, Rupp J, Kopp MV, Herting E, Göpel W. Front Pediatr. 2016 Nov 30;4:130.

Susceptibility to cephalosporin combinations and aztreonam/avibactam among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission. Mischnik A, Baumert P, Hamprecht A, Rohde A, Peter S, Feihl S, Knobloch J, Gölz H, Kola A, Obermann B, Querbach C, Willmann M, Gebhardt F, Tacconelli E, Gastmeier P, Seifert H, Kern WV; DZIF-ATHOS Study Group. Int J Antimicrob Agents. 2016 Nov 28. pii: S0924-8579(16)30349-1. doi: 10.1016/j.ijantimicag.2016.10.013.

Susceptibility to penicillin derivatives among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission. Mischnik A, Baumert P, Hamprecht A, Rohde A, Peter S, Feihl S, Knobloch J, Gölz H, Kola A, Obermann B, Querbach C, Willmann M, Gebhardt F, Tacconelli E, Gastmeier P, Seifert H, Kern WV; DZIF-ATHOS Study Group. Diagn Microbiol Infect Dis. 2016 Sep 23. pii: S0732-8893(16)30311-X. doi: 10.1016/j.diagmicrobio.2016.09.012. [Epub ahead of print]

Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study.Aliberti S, Reyes LF, Faverio P, Sotgiu G, Dore S, Rodriguez AH, Soni NJ, Restrepo MI; GLIMP investigators. Lancet Infect Dis. 2016 Sep 1. pii: S1473-3099(16)30267-5. doi: 10.1016/S1473-3099(16)30267-5. [Epub ahead of print]

Impact of micro-environmental changes on respiratory tract infections caused by intracellular bacteria. Shima K, Coopmeiners J, Graspeuntner S, Dalhoff K, Rupp J. FEBS Lett. 2016 Aug 10. doi: 10.1002/1873-3468.12353. [Epub ahead of print] Review.

Chlamydia trachomatis as the Cause of Infectious Infertility: Acute, Repetitive or Persistent Long-Term Infection? Schuchardt L, Rupp J. Curr Top Microbiol Immunol. 2016 Jul 2. [Epub ahead of print]

Inverse Correlation between IL-10 and HIF-1α in Macrophages Infected with Histoplasma capsulatum. Fecher RA, Horwath MC, Friedrich D, Rupp J, Deepe GS Jr. J Immunol. 2016 Jun 6. pii: 1600342. [Epub ahead of print]

Colonization with third-generation cephalosporin-resistant Enterobacteriaceae on hospital admission: prevalence and risk factors. Hamprecht A, Rohde AM, Behnke M, Feihl S, Gastmeier P, Gebhardt F, Kern WV, Knobloch JK, Mischnik A, Obermann B, Querbach C, Peter S, Schneider C, Schröder W, Schwab F, Tacconelli E, Wiese-Posselt M, Wille T, Willmann M, Seifert H, Zweigner J; DZIF-ATHOS Study Group. J Antimicrob Chemother. 2016 Jun 17. pii: dkw216. [Epub ahead of print]

Infektionen nach Organtransplantation. Cakiroglu F, Rupp J, Nitschke M. Notfall Rettungsmed 2016. DOI 10.1007/s10049-016-0241-y

Treatment with rhDNase in patients with cystic fibrosis alters in-vitro CHIT-1 activity of isolated leucocytes. Weckmann M, Schultheiss C, Hollaender A, Bobis I, Rupp J, Kopp MV. Clin Exp Immunol. 2016 Jun 20. doi: 10.1111/cei.12827. [Epub ahead of print]

Regulatory T-cell frequencies are increased in preterm infants with clinical early onset sepsis. Pagel J, Hartz A, Figge J, Gille C, Eschweiler S, Petersen K, Schreiter L, Hammer J, Karsten CM, Friedrich D, Herting E, Göpel W, Rupp J, Härtel C. Clin Exp Immunol. 2016 May 10. doi: 10.1111/cei.12810.

In vitro permissiveness of bovine neutrophils and monocyte derived macrophages to Leishmania donovani of Ethiopian isolate. Tasew G, Gadisa E, Abera A, Zewude A, Chanyalew M, Aseffa A, Abebe M, Ritter U, van Zandbergen G, Laskay T, Tafess K. Parasit Vectors. 2016 Apr 18;9(1):218. doi: 10.1186/s13071-016-1441-5.

Media Stories on NICU Outbreaks Lead to an Increased Prescription Rate of Third-Line Antibiotics in the Community of Neonatal Care. Härtel C, Hartz A, Bahr L, Gille C, Gortner L, Simon A, Orlikowsky T, Müller A, Körner T, Henneke P, Haase R, Zemlin M, Viemann D, Gebauer C, Thome U, Ziegler A, Rupp J, Herting E, Göpel W; German Neonatal Network. Infect Control Hosp Epidemiol. 2016 May 4:1-7.

A systemic defect in toll-like receptor 4 signaling increases lipopolysaccharide-induced suppression of IL-2-dependent T-cell proliferation in COPD. Knobloch J, Chikosi SJ, Yanik S, Rupp J, Jungck D, Koch A. Am J Physiol Lung Cell Mol Physiol 2016 Jan 1;310(1):L24-39.

Transcription regulates HIF-1α expression in CD4+ T cells. Bollinger  T, Bollinger A, Gies S, Feldhoff L, Solbach W, Rupp J. Immunol Cell Biol. 2016 Jan;94(1):109-13.

Impact of pneumococcal vaccination in children on serotype distribution in adult community-acquired pneumonia using the serotype-specific multiplex urinary antigen detection assay. Pletz MW, Ewig S, Rohde G, Schuette H, Rupp J, Welte T, Suttorp N, Forstner C; CAPNETZ Study Group. Vaccine. 2016 Apr 29;34(20):2342-8.

[CAPNETZ : The competence network for community-acquired pneumonia (CAP)]. Suttorp N, Welte T, Marre R, Stenger S, Pletz M, Rupp J, Schütte H, Rohde G; CAPNETZ- Studiengruppe. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2016 Apr;59(4):475-81. doi: 10.1007/s00103-016-2318-7.

IL-16 and MIF: messengers beyond neutrophil cell death.Roth S, Solbach W, Laskay T. Cell Death Dis. 2016 Jan 14;7:e2049. doi: 10.1038/cddis.2015.388.

Community-acquired Haemophilus influenzae pneumonia - New insights from the CAPNETZ study. Forstner C, Rohde G, Rupp J, Schuette H, Ott SR, Hagel S, Harrison N, Thalhammer F, von Baum H, Suttorp N, Welte T, Pletz MW; CAPNETZ Study Group. J Infect. 2016 Mar 3. pii: S0163-4453(16)00060-8. doi: 10.1016/j.jinf.2016.02.010.

NOD2 polymorphisms and the risk of necrotizing enterocolitis in very-low-birth-weight infants- a population-based cohort study. Härtel C, Hartz A, Pagel J, Rupp J, Stein A, Kribs A, Müller A, Haase R, Gille C, Böttger R, Kittel J, Jensen R, Wieg C, Herting E, and Göpel W for the German Neonatal Network (GNN). Inflamm Bowel Dis 2016 Feb;22(2):249-56.

Infektionen nach Organtransplantation. Cakiroglu F, Rupp J, Nitschke M. Notfall Rettungsmed 2016. DOI 10.1007/s10049-016-0241-y.


Production, crystallization and X-ray diffraction analysis of the protease CT441 from Chlamydia trachomatis. Kohlmann F, Shima K, Rupp J, Solbach W, Hilgenfeld R, Hansen G. Acta Crystallogr F Struct Biol Commun. 2015 Dec 1;71(Pt 12):1454-8. 

Early oral switch therapy in low-risk Staphylococcus aureus bloodstream infection (SABATO): study protocol for a randomized controlled trial. Kaasch AJ, Fätkenheuer G, Prinz-Langenohl R, Paulus U, Hellmich M, Weiß V, Jung N, Rieg S, Kern WV, Seifert H; SABATO trial group. Trials. 2015 Oct 9;16:450. doi: 10.1186/s13063-015-0973-x.

Budesonide Inhibits Intracellular Infection with Non-Typeable Haemophilus influenzae despite Its Anti-Inflammatory Effects in Respiratory Cells and Human Lung Tissue: A Role for p38 MAP Kinase. Wagner C, Goldmann T, Rohmann K, Rupp J, Marwitz S, Rotta Detto Loria J, Limmer S, Zabel P, Dalhoff K, Drömann D. Respiration. 2015;90(5):416-25.

Mechanisms of apoptosis inhibition in Chlamydia pneumoniae-infected neutrophils. Sarkar A, Möller S, Bhattacharyya A, Behnen M, Rupp J, van Zandbergen G, Solbach W, Laskay T. Int J Med Microbiol. 2015 Sep;305(6):493-500.

AP-1 transcription factor serves as a molecular switch between Chlamydia pneumoniae replication and persistence. Krämer S, Crauwels P, Bohn R, Radzimski C, Szaszák M, Klinger M, Rupp J, van Zandbergen G. Infect Immun. 2015 Jul;83(7):2651-60.

Genomic factors related to tissue tropism in Chlamydia pneumoniae infection. Weinmaier T, Hoser J, Eck S, Kaufhold I, Shima K, Strom TM, Rattei T, Rupp J. BMC Genomics. 2015 Apr 7;16:268.

Community-acquired pneumonia as medical emergency: predictors of early deterioration. Kolditz M, Ewig S, Klapdor B, Schütte H, Winning J, Rupp J, Suttorp N, Welte T, Rohde G; CAPNETZ study group. Thorax. 2015 Jun;70(6):551-8.

Randomized double blind placebo-controlled study to demonstrate that antibiotics are not needed in moderate acute exacerbations of COPD--the ABACOPD study. Rohde GG, Koch A, Welte T; ABACOPD study group. BMC Pulm Med. 2015 Jan 27;15:5. doi: 10.1186/1471-2466-15-5.

The role of ER-related BiP/GRP78 in IFN-γ induced persistent Chlamydia pneumoniae infection. Shima K, Klinger M, Schütze S, Kaufhold I, Solbach W, Reiling N, Rupp J. Cell Microbiol. 2015 Jul;17(7):923-34.

Mycoplasma pneumoniae and Chlamydia spp. Infection in Community-Acquired Pneumonia, Germany, 2011-2012. Dumke R, Schnee C, Pletz MW, Rupp J, Jacobs E, Sachse K, Rohde G, Group CS. Emerg Infect Dis. 2015 Mar;21(3):426-34. doi: 10.3201/eid2103.140927.

Structural Basis of the Proteolytic and Chaperone Activity of Chlamydia trachomatis CT441. Kohlmann F, Shima K, Hilgenfeld R, Solbach W, Rupp J, Hansen G. J Bacteriol. 2015 Jan 1;197(1):211-8. doi: 10.1128/JB.02140-14. Epub 2014 Oct 27.

Risk assessment of tuberculosis in immunocompromised patients. A TBNET study. Sester M, van Leth F, Bruchfeld J, Bumbacea D, Cirillo DM, Dilektasli AG, Domínguez J, Duarte R, Ernst M, Eyuboglu FO, Gerogianni I, Girardi E, Goletti D, Janssens JP, Julander I, Lange B, Latorre I, Losi M, Markova R, Matteelli A, Milburn H, Ravn P, Scholman T, Soccal PM, Straub M, Wagner D, Wolf T, Yalcin A, Lange C; TBNET. Am J Respir Crit Care Med. 2014 Nov 15;190(10):1168-76. doi: 10.1164/rccm.201405-0967OC.

Borel N, Pospischil A, Hudson AP, Rupp J, Schoborg RV. The role of viable but non-infectious developmental forms in chlamydial biology. Front Cell Infect Microbiol. 2014 Jul 24;4:97. doi: 10.3389/fcimb.2014.00097.

Härtel C, Pagel J, Rupp J, Bendiks M, Guthmann F, Rieger-Fackeldey E, Heckmann M, Franz A, Schiffmann JH, Zimmermann B, Hepping N, von der Wense A, Wieg C, Herting E, Göpel W; German Neonatal Network. Prophylactic Use of Lactobacillus acidophilus/Bifidobacterium infantis Probiotics and Outcome in Very Low Birth Weight Infants. J Pediatr. 2014  Aug;165(2):285-289.e1. doi: 10.1016/j.jpeds.2014.04.029.

Käding N, Szaszak M, Rupp J. Imaging of Chlamydiae and host cell metabolism. Future Microbiol 2014 Apr;9:509-21. doi: 10.2217/fmb.14.13.

Jerchel S, Kaufhold I, Schuchardt L, Shima K, Rupp J. Host immune responses after hypoxic reactivation of IFN-γ induced persistent Chlamydia trachomatis infection. Front Cell Infect Microbiol 2014; Apr 16;4:43. doi: 10.3389/fcimb.2014.00043.

Bollinger T, Gies S, Naujoks J, Feldhoff L, Bollinger A, Solbach W, Rupp J. HIF-1α- and hypoxia-dependent immune responses in human CD4+CD25high T-cells and T-helper 17 cells. J Leukoc Biol 2014 Aug;96(2):305-12. doi: 10.1189/jlb.3A0813-426RR.

Bermbach S, Weinhold K, Roeder T, Petersen F, Kugler C, Goldmann T, Rupp J, König P. Mechanism of Cilia-Driven Transport in the Airways in the Absence of Mucus. Am J Respir Cell Mol Biol. 2014 Jul;51(1):56-67. doi: 10.1165/rcmb.2012-0530OC.


Rotta detto Loria J, Rohmann K, Droemann D, Kujath P, Rupp J, Goldmann T, Dalhoff K. Nontypeable Haemophilus Influenzae infection upregulates the NLRP3 inflammasome and leads to Caspase-1-dependent secretion of interleukin-1β - A possible pathway of exacerbations in COPD. PLoS One. 2013, Jun 26;8(6):e66818. Print 2013.

Schmidt SK, Ebel S, Keil E, Woite C, Ernst JF, Benzin AE, Rupp J, Däubener W. Regulation of IDO activity by oxygen supply: Inhibitory effects on antimicrobial and immunoregulatory functions. PLoS One. 2013, May 13;8(5):e63301.

Szaszák M, Shima K, Käding N, Hannus M, Solbach W, Rupp, J. Host metabolism promotes growth of Chlamydia pneumoniae in a low oxygen environment. Int J Med Microbiol. 2013; Jul;303(5):239-46.

Shima K, Klinger M, Solbach W, Rupp J. Activity of first choice antimicrobials against IFN-γ treated Chlamydia trachomatis differs in hypoxia. Antimicrob Agents Chemother 2013; Jun;57(6):2828-30.

Haas CS, Lehne W, Muck P, Boehm A, Rupp J, Steinhoff J, Lehnert H. Acute kidney injury and thrombocytopenic fever-consider the infrequent causes. Am J Emerg Med 2013, Feb; 31(2):441.

Szaszak M, Chang JC, Leng W, Rupp J, Ojcius DM, Kelley AM. Characterizing the intracellular distribution of metabolites in intact chlamydia- infected cells by Raman and two-photon microscopy. Microbes Infect 2013; Jun;15(6-7):461-9.

Müller C, Dietz I, Tzotis D, Moritz F, Rupp J, Schmitt-Kopplin P. Molecular cartography in acute Chlamydia pneumoniae infections- a non-targeted metabolomics approach. Anal Bioanal Chem 2013, Jan 27, Jun;405(15):5119-31.


Härtel C, Kopp M, Herting E, Rupp J. Rationaler Einsatz von Antibiotika bei Kindern. Praktische Pädiatrie. 2012;18:143-150.

Puzik A, Rupp J, Tröger B, Göpel W, Herting E, Härtel C. Insulin-like growth factor-I regulates the neonatal immune response in infection and maturation by suppression of IFN-γ. Cytokine. 2012; 60:369-76.

Jerchel S, Knebel G, König P, Bohlmann MK, Rupp J. A Human Fallopian Tube Model for Investigation of C. trachomatis Infections. J Vis Exp 2012;66: e4036.

Nitschke M, Sayk F, Härtel C, Roseland RT, Hauswaldt S, Steinhoff J, Fellermann K, Derad I, Wellhöner P, Büning J, Tiemer B, Katalinic A, Rupp J, Lehnert H, Solbach W, Knobloch JK. Association between azithromycin therapy and duration of bacterial shedding among patients with Shiga toxin-producing enteroaggregative Escherichia coli O104:H4. JAMA. 2012 Mar 14;307(10):1046-52.

Dietz I, Jerchel S, Szaszak M, Shima K, Rupp J. When oxygen runs short: the microenvironment drives host-pathogen interactions. Microbes Infect. 2012 Apr;14(4):311-6.


Christian JG, Heymann J, Paschen SA, Vier J, Schauenburg L, Rupp J, Meyer TF, Häcker G, Heuer D. Targeting of a chlamydial protease impedes intracellular bacterial growth. PLoS Pathog. 2011 Sep;7(9):e1002283.

Abdullah M, Kähler D, Vock C, Reiling N, Kugler C, Drömann D, Rupp J, Hauber HP, Fehrenbach H, Zabel P, Vollmer E, Dalhoff K, Goldmann T. Pulmonary Haptoglobin and CD163 Are Functional Immunoregulatory Elements in the Human Lung. Respiration. 2011 Aug 22.

Rupp J, Schaaf B. [Infections with nontuberculous mycobacteria in patients with immune deficiencies]. Pneumologe 2011;8:412-417

Dietz I, Jerchel S, Rupp J. [Die Bedeutung von Sauerstoff und HIF-1α für Infektionsprozesse]. Mikrobiologe 2011; 21(4):109

Szaszák M, Steven P, Shima K, Orzekowsky-Schröder R, Hüttmann G, König IR, Solbach W, Rupp J. Fluorescence lifetime imaging unravels C. trachomatis metabolism and its crosstalk with the host cell. PLoS Pathog. 2011 Jul;7(7):e1002108.

Dalhoff K, Rupp J. [Threat posed by coinfection of HIV and TB]. Pneumologe 2011;8:32-39

Shima K, Szaszák M, Solbach W, Gieffers J, Rupp J. Impact of a low oxygen environment on the efficacy of antimicrobials against intracellular Chlamydia trachomatis. Antimicrob Agents Chemother. 2011 May;55(5):2319-24.

Witte L, Droemann D, Dalhoff K, Rupp J. C. pneumoniae is frequently detected in the blood after acute lung infection. Eur Respir J 2011 Mar;37(3):712-4

Knobloch J, Schild K, Jungck D, Urban K, Müller K, Schweda EK, Rupp J, Koch A. The T-Helper Cell Type 1-Immune Response to Gram-Negative Bacterial Infections is Impaired in COPD. Am J Respir Crit Care Med. 2011 Jan 15;183(2):204-14


Roth A, König P, van Zandbergen G, Klinger M, Hellwig-Bürgel T, Däubener W, Bohlmann MK, Rupp J. Hypoxia abrogates antichlamydial properties of IFN-gamma in human fallopian tube cells in vitro and ex vivo. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19502-7

Shima K, Kuhlenbäumer G, Rupp J. Chlamydia pneumoniae infection and Alzheimer's disease: a connection to remember? Med Microbiol Immunol. 2010 Nov;199(4):283-9

Bellmann-Weiler R, Martinz V, Kurz K, Engl S, Feistritzer C, Fuchs D, Rupp J, Paldanius M, Weiss G. Divergent modulation of Chlamydia pneumoniae infection cycle in human monocytic and endothelial cells by iron, tryptophan availability and interferon gamma. Immunobiology 2010 Sep-Oct;215(9-10):842-8.

Dromann D, Rupp J, Rohmann K, Osbahr S, Ulmer AJ, Marwitz S, Roschmann K, Abdullah M, Schultz H, Vollmer E, Zabel P, Dalhoff K, Goldmann T. The TGF-beta-Pseudoreceptor BAMBI is strongly expressed in COPD lungs and regulated by nontypeable Haemophilus influenzae. Respir Res. 2010 May 31;11(1):67.

Rupp J, Kramme E, Schultz H, Schaaf B. [Diagnostics for fungal infections of the lungs]. Pneumologie. 2010 May;64(5):300-10.

Bunk S, Schaffert H, Schmid B, Goletz C, Zeller S, Borisova M, Kern F, Rupp J, Hermann C. Chlamydia pneumoniae-induced memory CD4+ T cell activation in human peripheral blood correlates with distinct antibody response patterns. Clin Vaccine Immunol. 2010 May;17(5):705-12.

Borcherding F, Nitschke M, Hundorfean G, Rupp J, von Smolinski D, Bieber K, van Kooten C, Lehnert H, Fellermann K, Büning J. The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease. Am J Pathol. 2010 Apr;176(4):1816-27.


Rupp J, Pfleiderer L, Jugert C, Moeller S, Klinger M, Dalhoff K, Solbach W, Stenger S, Laskay T, van Zandbergen G. Chlamydia pneumoniae hides inside apoptotic neutrophils to silently infect and propagate in macrophages. PLoS One. 2009 Jun 23;4(6):e6020

Kern JM, Maass V, Rupp J, Maass M. Proliferative stimulation of the vascular Endothelin-1 axis in vitro and ex vivo by infection with Chlamydia pneumoniae. Thromb Haemost. 2009 Oct;102(4):743-53.

Rupp J, Härtel C, Iblher P, Puzik A, Osthues I, Schultz C, Müller-Steinhardt M. Immunomodulatory effects of Sanglifehrin A in the innate and acquired immune response of neonatal whole blood cells. Immunobiology. 2009;214(3):235-43.


Strassburg A, Rupp J, Herth FJ, Magnussen H, Zabel P, Lange C. [Infection diagnostics in pneumology. Part 1. Survey and methods]. Pneumologie. 2008 Dec;62(12):730-43.

Rohde G, Rupp J. [Infections and asthma] Internist (Berl). 2008 Nov;49(11):1302, 1304-6, 1308-9.

Schultz C, Zimmer J, Härtel C, Rupp J, Temming P, Strunk T. Attenuation of monocyte proinflammatory cytokine responses to Neisseria meningitidis in children by erythropoietin. Clin Exp Immunol. 2008 Nov;154(2):187-91.

Xu F, Droemann D, Rupp J, Shen H, Wu X, Goldmann T, Hippenstiel S, Zabel P, Dalhoff K. Modulation of the Inflammatory Response to S. pneumoniae in a Model of Acute Lung Tissue Infection. Am J Respir Cell Mol.Biol. 2008 Nov;39(5):522-9.

Härtel C, Rupp J, Hoegemann A, Bohler A, Spiegler J, von Otte S, Röder K, Schultz C, Göpel W. 159C>T CD14 genotype--functional effects on innate immune responses in term neonates. Hum Immunol. 2008 Jun;69(6):338-43.

Witte L, Rupp J, Heyer P, Dalhoff K, Schaaf B. [Fibrosing alveolitis with hepatitis C-related cryoglobulinemia.] Dtsch Med Wochenschr. 2008 Apr;133(14):709-12.

Bunk S, Susnea I, Rupp J, Summersgill JT, Maass M, Stegmann W, Schrattenholz A, Wendel A, Przybylski M, Hermann C. Immunoproteomic identification and serological responses to novel Chlamydia pneumoniae antigens that are associated with persistent C. pneumoniae infections. J Immunol. 2008 Apr 15;180(8):5490-8.

Steven P, Rupp J, Hüttmann G, Koop N, Lensing C, Laqua H, Gebert A. Experimental induction and three-dimensional two-photon imaging of conjunctiva-associated lymphoid tissue. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1512-7.

Härtel C, Osthues I, Rupp J, Haase B, Röder K, Göpel W, Herting E, Schultz C. Characterization of the host inflammatory response to Staphylococcus epidermidis in neonatal whole blood.
Arch Dis Child Fetal Neonatal Ed. 2008 Mar;93(2):F140-5.

Rupp J, Solbach W, Gieffers J. Variation in the mutation frequency determining quinolone resistance in Chlamydia trachomatis serovars L2 and D. J Antimicrob Chemother 2008 Jan;61(1):91-4.


Rattei T, Ott S, Gutacker M, Rupp J, Maass M, Schreiber S, Solbach W, Wirth T, Gieffers J. Genetic diversity of the obligate intracellular bacterium Chlamydophila pneumoniae by genome-wide analysis of single nucleotide polymorphisms: evidence for highly clonal population structure. BMC Genomics. 2007 Oct 4;8:355.

Rupp J, Solbach W, Gieffers J. Prevalence, genetic conservation and transmissibility of the Chlamydia pneumoniae bacteriophage (phiCpn1). FEMS Microbiol Lett. 2007 Aug;273(1):45-9.

Dalhoff K, Rupp J. Nocardiosis. Pneumologe 2007;4:424-431.

Schaaf B, Kruse J, Rupp J, Reinert RR, Droemann D, Zabel P, Ewig S, Dalhoff K. Sepsis severity predicts outcome in community acquired pneumococcal pneumonia. Eur Respir J. 2007 Sep;30(3):517-24.

Rupp J, Gieffers J, Klinger M, van Zandbergen G, Wrase R, Maass M, Solbach W, Deiwick J, Hellwig-Burgel T. Chlamydia pneumoniae directly interferes with HIF-1alpha stabilization in human host cells. Cell Microbiol. 2007 Sep;9(9):2181-91.

Droemann D, Rupp J, Goldmann T, Uhlig U, Branscheid D, Vollmer E, Kujath P, Zabel P, Dalhoff K.
Disparate innate immune responses to persistent and acute Chlamydia pneumoniae infection in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2007 Apr 15;175(8):791-7.

Schaaf B, Rupp J. [Diagnosis of community-acquired pneumonia] Pneumologie. 2006;60(9):547-54.


Wissel H, Burkhardt W, Rupp J, Wauer RR, Rudiger M. Perfluorocarbons Decrease Chlamydophila pneumoniae-Mediated Inflammatory Responses of Rat Type II Pneumocytes In Vitro. Pediatr Res. 2006;60(3):264-9.

Schaaf B, Rupp J. [Diagnosis of community-acquired pneumonia.] Pneumologie. 2006 Sep;60(9):547-54; quiz 555-8.

Rupp J, Fenner I, Solbach W, Gieffers J. Be aware of the possibility of false-positive results in single-locus PCR assays for methicillin-resistant Staphylococcus aureus. J Clin Microbiol. 2006 Jun;44(6):2317.

Schubel N, Rupp J, Gottschalk S, Zabel P, Dalhoff K. Disseminated mycobacterium bovis infection in an immunocompetent host. Eur J Med Res. 2006 Apr 28;11(4):163-6.

Rupp J, Solbach W, Gieffers J. Single-nucleotide-polymorphism-specific PCR for quantification and discrimination of Chlamydia pneumoniae genotypes by use of a "locked" nucleic acid. Appl Environ Microbiol. 2006 May;72(5):3785-7.


Goldmann T, Dromann D, Marzouki M, Schimmel U, Debel K, Branscheid D, ZeiserT, Rupp J, Gerdes J, Zabel P, Vollmer E. Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material. Pathol Res Pract. 2005;201(8-9):599-602.

von Aulock S, Rupp J, Gueinzius K, Maass M, Hermann C. Critical investigation of the CD14 promoter polymorphism: lack of a role for in vitro cytokine response and membrane CD14 expression. Clin Diagn Lab Immunol. 2005 Oct;12(10):1254-6.

Hauber HP, Galle J, Chiodini PL, Rupp J, Birke R, Vollmer E, Zabel P, Lange C. Fatal outcome of a hyperinfection syndrome despite successful eradication of Strongyloides with subcutaneous ivermectin. Infection. 2005 Oct;33(5-6):383-6.

Krull M, Maass M, Suttorp N, Rupp J. Chlamydophila pneumoniae. Mechanisms of target cell infection and activation. Thromb Haemost. 2005 Aug;94(2):319-26. Review.

Schaaf B, Rupp J, Muller-Steinhardt M, Kruse J, Boehmke F, Maass M, Zabel P, Dalhoff K. The interleukin-6 -174 promoter polymorphism is associated with extrapulmonary bacterial dissemination in Streptococcus pneumoniae infection. Cytokine. 2005 Aug 21;31(4):324-8.

Siewert K, Rupp J, Klinger M, Solbach W, Gieffers J. Growth cycle-dependent pharmacodynamics of antichlamydial drugs. Antimicrob Agents Chemother. 2005 May;49(5):1852-6.

Droemann D, Rupp J, Goldmann T, Maass M, Vollmer E, Zabel P, Dalhoff K. [Pulmonary infections in human lung tissue models.] Pneumologie 2005 Jun;59(6):422-4.

Rupp J, Hellwig-Burgel T, Wobbe V, Seitzer U, Brandt E, Maass M. Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3447-52.

Rupp J, Koch M, van Zandbergen G, Solbach W, Brandt E, Maass M. Transmission of Chlamydia pneumoniae infection from blood monocytes to vascular cells in a novel transendothelial migration model. FEMS Microbiol Lett. 2005 Jan 15;242(2):203-8. Erratum in: FEMS Microbiol Lett. 2005 Sep 1;250(1):171. vanZandbergen, Ger [corrected to van Zandbergen, Ger].

Rupp J, Gebert A, Solbach W, Maass M. Serine-to-asparagine substitution in the GyrA gene leads to quinolone resistance in moxifloxacin-exposed Chlamydia pneumoniae. Antimicrob Agents Chemother. 2005 Jan;49(1):406-7.

Mitusch R, Luedemann J, Wood WG, Berger K, Schminke U, Suter M, Kessler C, John U, Rupp J, Kentsch M, Maass M. Asymptomatic carotid atherosclerosis is associated with circulating chlamydia pneumoniae DNA in younger normotensive subjects in a general population survey. Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):386-91.


Rupp J, Berger M, Reiling N, Gieffers J, Lindschau C, Haller H, Dalhoff K, Maass M. Cox-2 inhibition abrogates Chlamydia pneumoniae-induced PGE2 and MMP-1 expression. Biochem Biophys Res Commun. 2004 Jul 30;320(3):738-44.

Rupp J, Droemann D, Goldmann T, Zabel P, Solbach W, Vollmer E, Branscheid D, Dalhoff K, Maass M. Alveolar epithelial cells type II are major target cells for C. pneumoniae in chronic but not in acute respiratory infection. FEMS Immunol Med Microbiol. 2004 Jul 1;41(3):197-203.

Gieffers J, van Zandbergen G, Rupp J, Sayk F, Kruger S, Ehlers S, Solbach W, Maass M. Phagocytes transmit Chlamydia pneumoniae from the lungs to the vasculature. Eur Respir J. 2004 Apr;23(4):506-10.

Dittrich R, Dragonas C, Mueller A, Maltaris T, Rupp J, Beckmann MW, Maass M. Endothelial Chlamydia pneumoniae infection promotes oxidation of LDL.Biochem Biophys Res Commun. 2004 Jun 25;319(2):501-5.

Ince A, Rupp J, Frommelt L, Katzer A, Gille J, Lohr JF. Is "aseptic" loosening of the prosthetic cup after total hip replacement due to nonculturable bacterial pathogens in patients with low-grade infection? Clin Infect Dis. 2004 Dec 1;39(11):1599-603.

Gieffers J, Rupp J, Gebert A, Solbach W, Klinger M. First-choice antibiotics at subinhibitory concentrations induce persistence of Chlamydia pneumoniae. Antimicrob Agents Chemother. 2004 Apr;48(4):1402-5.

van Zandbergen G, Gieffers J, Kothe H, Rupp J, Bollinger A, Aga E, Klinger M, Brade H, Dalhoff K, Maass M, Solbach W, Laskay T. Chlamydia pneumoniae multiply in neutrophil granulocytes and delay their spontaneous apoptosis. J Immunol. 2004 Feb 1;172(3):1768-76.


Gieffers J, Durling L, Ouellette SP, Rupp J, Maass M, Byrne GI, Caldwell HD, Belland RJ. Genotypic differences in the Chlamydia pneumoniae tyrP locus related to vascular tropism and pathogenicity. J Infect Dis. 2003 Oct 15;188(8):1085-93. Epub 2003 Oct 10.

Rupp J, Kothe H, Mueller A, Maass M, Dalhoff K. Imbalanced secretion of IL-1beta and IL-1RA in Chlamydia pneumoniae-infected mononuclear cells from COPD patients. Eur Respir J. 2003 Aug;22(2):274-9.

Rupp J, Reincke B, Schaaf B, Dalhoff K. [PET-imaging proves giant-cell arteritis as the cause of FUO in a patient with a pulmonary nodule of unknown malignancy. ] Pneumologie 2003 Jul;57(7):383-6.

Dechend R, Gieffers J, Dietz R, Joerres A, Rupp J, Luft FC, Maass M. Hydroxymethylglutaryl coenzyme A reductase inhibition reduces Chlamydia pneumoniae-induced cell interaction and activation. Circulation. 2003 Jul 22;108(3):261-5.

Rupp J, Maass M. Egr-1, a major link between infection and atherosclerosis? Circ Res. 2003 May 16;92(9):e78.


Kothe H, Dalhoff K, Rupp J, Muller A, Kreuzer J, Maass M, Katus HA. Hydroxymethylglutaryl coenzyme A reductase inhibitors modify the inflammatory response of human macrophages and endothelial cells infected with Chlamydia pneumoniae. Circulation. 2000 Apr 18;101(15):1760-3.